Olga Tarasova

Abstract: Stenosis or occlusion of carotid arteries because of their atherosclerotic lesions leads to chronic brain hypoperfusion, dysfunctions of the cerebral vasculature and nerve centers involved in the regulation of systemic hemodynamics. In addition, stenosis of carotid arteries disrupts the functioning of the sinocarotid baroreflex, which increasesblood pressure variability and can aggravate pathological changes in both systemic and cerebral circulation. In my report, I will present data on the regulation of cerebral and systemic hemodynamics in patients with carotid stenosis, as well as those obtained in an animal model of this pathology (vascular studies with the use of in vitro and in vivo techniques). Importantly,our data show the character of the observed changes may be either detrimental or compensatory, depending on the duration and severity of the disease. This should be considered when assessing the degree of cerebral vasoregulation disorder and predicting the course of this disease. The work was supported by a grant from the Russian Science Foundation, # 23-15-00331.

Speaker: Olga Tarasova — Head of the Department of Physiology and Pathology, Faculty of Basic Medicine, Lomonosov Moscow State University (MSU) and chief researcher at the Laboratory of Exercise Physiology, Institute of Biomedical Problems. In 1984, she graduated from the Department of Biology at MSU, qualifying as a physiologist. Received a Candidate of Science degree in 1990 and a Doctor of Science degree in 2005.The field of research interests – physiology of circulation and autonomic nervous system. In 1995, during a visit to Sweden and Denmark, she mastered the method of wire myography, then implemented it in MSU for experiments tiny arterial vessels.PIof many research projects supported by the Russian Foundation for Basic Research and the Russian Science Foundation.Laureate of the V.V. Parin Prize (Presidium of RAS) for the work "Regulation of blood circulation during adaptation to extreme conditions". In recent years, her research team has been focused on alterations of vascular control in challenges of perinatal development and hypokinesia (conditions of microgravity), including their detrimental effects on cerebral vasculature.