Madaeva Irina

Abstract: Obstructive sleep apnea (OSA) is very serious and multifactorial sleep disorder which closely related with disruption of sleep homeostasis. It is known that such sleep encephalographic (EEG) phenomenon as sleep spindles (SSs) support sleep stability and may display a sleep protective function. Thus, it is of particular interest to assess the SSs pattern in OSA patient that was the aim of the present research. We investigated whether SS activity could be altered in patient with moderate degree of OSA compared with non-OSA subjects. 35 middle-aged OSA patients and 30 controls underwent full-night polysomnography (PSG). SSs were automatically detected during stage 2 (N2) of non-rapid eye movements. The SSs activity characteristics involved: total number, mean density, mean maximum amplitude and mean frequency. All differences were considered statistically significant at p <0.05. We noted a significant decrease in the density and number of central SSs in patients with OSA compared to controls, however, the amplitude is significantly higher in OSA subjects. To summarize, our results show that OSA lead to significant disruption of SSs density, reduction of their number and frequency in N2 sleep stages. These findings can be evidence of the extinction of a brain protective mechanism against exciting stimuli during apnea episodes in OSA patients with a long duration of sleep disturbances.

Speaker: Irina M. Madaeva, MD, PhD, is a Head of Irkutsk Somnological center, chief researcher of somnological and neurophysiological department of Federal State Public «Scientific Center for Family Health and Human Reproduction Problems», Irkutsk , Russia. She obtained her Ph.D. (1994) and D.Sc. (2009) in sleep medicine. Research interests include relationship between aging and sleep, modifying factors of sleep disorders, molecular mechanisms of sleep disorders, melatonin circadian rhythms, ethnic aspects of sleep disorders. Madaeva I.M. is scientific supervision of 7 scientific theses. She is member of World Association of Sleep Medicine. She is the Heard of Scientific Committee of Russian Society of Sleep Medicine . She is author more than 200 scientific papers in peer-reviewed journals, from them 162 publications in bases Web of Sciences and Scopus, Q 1-2.