Tingting YU
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology (HUST, Wuhan, China)
Abstract: Acquiring the three-dimensional (3D) structure of biological tissues is essential for research in life sciences. Modern optical imaging techniques and fluorescent labeling technologies have provided vital tools for obtaining high-resolution information on the 3D structures of biological tissues. However, the turbid nature of biological tissues limits the depth of light penetration, leading to restricted applications for large tissues or whole organs. Tissue optical clearing technology takes a different approach by making the tissues transparent using various physical and chemical strategies to reduce the attenuation of light in tissues, and providing a new approach for the 3D imaging of whole tissue organs. Here, we will introduce our progress in the research of ex vivo tissue optical clearing methods and applications, covering the fluorescence labeling, tissue clearing, and imaging of whole organs.
Speaker: Tingting Yu is an Associate Researcher at the Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology. She is mainly engaged in research on tissue optical clearing methods and applications, focusing on the development of optical imaging techniques based on tissue clearing for obtaining and reconstructing three-dimensional structure information of the central nervous system, peripheral nervous system, and other biological tissues. She has published over 30 SCI papers in journals such as Science Advances, Nature Communications, and Theranostics, and has contributed to the compilation of four Chinese and English monographs, with five authorized patents. She has led projects including the General Project, Young Scientists Fund from NSFC, International Cooperation and Exchanges Projects from NSFC, and Hubei Province's Key R&D Program, as well as participating in Key R&D projects of the Ministry of Science and Technology and the Key International Cooperation Research Projects of NSFC. She is a Young Committee Member of the Biomedical Optics Division of the Chinese Society of Biomedical Engineering and a Young Committee Member of the Biomedical Optics Professional Committee of the Chinese Optical Society.