Dan Zhu

Abstract: Modern optical imaging techniques provide a powerful tool to observe cortical structure and functions with high resolution. Various of skull windows have been established for different applications of cortical imaging, and each has advantages and limitations. Even none of current skull windows can be suitable for observation of the responses to some acute craniocerebral injuries at large scale and high resolution. We developed a “Through-Intact-Skull (TIS) window”, which promises us to observe immune response after traumatic brain injury at bilateral cortical scale and single-cell resolution without affecting the pathological environment of the brain. Meanwhile, TIS window has all advantages of current skull windows, including craniotomy free, centimeter-field of view, synaptic resolution, large imaging depth, long-term observation capability and compatibility for awake mice. Therefore, TIS window will be a promising new approach for intravital cortical microscopy for basic research in neuroscience.

Speaker: Dan Zhu is Distinguished Professor of Huazhong University of Science and Technology, SPIE/OPTICA Fellow, Director of Advanced Biomedical Imaging Facility, Vice-director of Wuhan National Laboratory for Optoelectronics. She has been developing tissue optical clearing methods for obtaining in vivo cortical neurovascular structure and function, as well as 3D structure of organs. She has owned more than 200 peer-review papers in Science Advances、Nature Communications、Light: Science & Applications et al, and 100 plenary or invited talk on international conferences, including SPIE Bios Hot Topic. She is an Associate editor of Journal of Biomedical Optics,except executive Editor-in-Chief of Frontier of Optoelectronics：Biomedical Photonics，Editorial Member or Guest Editor of Biomedical Optics Express, Scientific Reports, Journal of Innovative Optical Health Sciences, and Frontier of Optoelectronics etc.