Speakers

Abstract: Acquiring the three-dimensional (3D) structure of biological tissues is essential for research in life sciences. Modern optical imaging techniques and fluorescent labeling technologies have provided vital tools for obtaining high-resolution information on the 3D structures of biological tissues. However, the turbid nature of biological tissues limits the depth of light penetration, leading to restricted applications for large tissues or whole organs. Tissue optical clearing technology takes a different approach by making the tissues transparent using various physical and chemical strategies to reduce the attenuation of light in tissues, and providing a new approach for the 3D imaging of whole tissue organs. Here, we will introduce our progress in the research of ex vivo tissue optical clearing methods and applications, covering the fluorescence labeling, tissue clearing, and imaging of whole organs.

Speaker: Tingting Yu is an Associate Researcher at the Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology. She is mainly engaged in research on tissue optical clearing methods and applications, focusing on the development of optical imaging techniques based on tissue clearing for obtaining and reconstructing three-dimensional structure information of the central nervous system, peripheral nervous system, and other biological tissues. She has published over 30 SCI papers in journals such as Science Advances, Nature Communications, and Theranostics, and has contributed to the compilation of four Chinese and English monographs, with five authorized patents. She has led projects including the General Project, Young Scientists Fund from NSFC, International Cooperation and Exchanges Projects from NSFC, and Hubei Province's Key R&D Program, as well as participating in Key R&D projects of the Ministry of Science and Technology and the Key International Cooperation Research Projects of NSFC. She is a Young Committee Member of the Biomedical Optics Division of the Chinese Society of Biomedical Engineering and a Young Committee Member of the Biomedical Optics Professional Committee of the Chinese Optical Society.

Abstract: MRI is a powerful method for neurophysiological studies, but the MRI experimental environment required to measure the data has a major impact on the conduct of the experiment and dramatically alters the physiology and behaviour of the participant. The closed loop, loud high frequency noise, fixed head, minimal body movement requirements, relaxed lying position and high-tech environment all put a lot of stress on the participant, but we expect them to ignore this and engage in the experiment. I'll give an overview of the MRI-induced changes in participants' perception, the processes of adaptation in the MRI and the physiological markers of good adaptation. We will review the samples of data recorded, reject the MRI induced artefacts and compare the results with the data recorded outside the MRI.

Speaker: Pavel Rudych is an engineer and project manager at Novosibirsk State University and the International Tomography Centre of Novosibirsk. Pavel received his M.S. in Physics from Novosibirsk State University, Russia, in 2005 and his second B.S. in Clinical Psychology in 2021. His research interests are in functional MRI and coregistered EEG experiments, experiment stimulus gamification and environmental transparency based on web, EEG/MRI data aggregation and automated processing, machine learning analysis. Pavel is the author of more than 30 peer-reviewed publications.

Abstract: Dizziness and vertigo: causes, diagnosis, principles of treatment Dizziness is a nonspecific symptom that describes a sensation of abnormal rotation of the head, or the sensation of the external environment spinning. It affects 50% of elderly patients and is the commonest cause of complaint in patients over 75 years of age. It may be physiological, occurring during or after a sustained head rotation, or pathological, due to vestibular dysfunction. It divided to peripheral and central. Peripheral vertigo is due to disorders that affect the labyrinths or vestibular nerves. Central vestibular causes are multiple sclerosis, migraine, epilepsy. Vertigo may be paroxysmal or chronic. In diagnosing the vertigo causes, we will use the data of physical examination, special tests, data of laboratory and instrumental examination. Treatment depends on the causes of dizziness.

Speaker: Tatyana Pronko, MD, PhD is a Head of the Department of Propaedeutics of Internal Diseases of Grodno State Medical University, Belarus since 2012. She defended scientific degree (PhD) "Study of endothelial dysfunction and blood oxygen transport system in patients with arterial hypertension and coronary artery disease” in 2003. Pronko T. is scientific supervisor of 1 scientific theses “Study of arterial stiffness in patients with arterial hypertension after ischemic stroke”. In the near future, two more people are planning to defend their thesis completed under her supervision. Current research interests include platelet aggregation, clinical and laboratory factors influencing high and low residual platelet reactivity in patients with myocardial infarction.She has over 290 publications, 22 of them are in Web of Sciences and Scopus bases. She is member of European Cardiology Society and Russian Cardiology Society.

Abstract: Secondary damage after traumatic brain injury is a serious problem in neurocritical care, which leads to increased neuroinflammation and cerebral edema. It is known that secondary brain lesions play a significant role in the pathogenesis of severe closed traumatic brain injury, leading to edema, increased intracranial pressure, dislocation of vital centers and unfavorable outcome.Despite a number of factors influencing the high mortality associated with traumatic brain injury, the development of cerebral edema is the most significant predictor of unfavorable outcome.Various pharmacological treatment options have not demonstrated benefit in traumatic brain injury.In this presentation, I will review clinical developments to target neuroinflammation and cerebral edema in traumatic brain injury in the context of recent progress made in the field of the glymphatic system of the brain.

Speaker: Olim Sh. Eshonov – Associate Professor of the Department of Anesthesiology and Reanimatology, Bukhara State Medical Institute.He underwent specialization and advanced training at the Institute of Emergency and Emergency Care named after. Sklifosovsky in Moscow 1984 1986, 1991 on the basis of the Moscow Medical Academy in the “Clinical Lymphology” cycle.In 1991, he defended his PhD thesis at the Moscow Medical Academy on the topic “Endolymphatic antibiotic therapy for acute septic brucellosis.”His research focuses on developing new treatments for traumatic brain injury, stroke and other cerebrovascular diseases.

Dr. Eshonov is the author of more than 150 publications and textbooks “Anesthesiology and Resuscitation” and “Emergency Conditions”, the manual “Anesthesiology, Resuscitation and Intensive Care”, received three patents for new methods of treating and diagnosing diseases.

Abstract: Acute ischemic stroke affects millions of people every year. Recent research data indicate the involvement of the glymphatic system in the process. The balance of pro- and anti-inflammatory interleukins is one of the pathogenetic mechanisms of the development of neuroinflammation that determines the course and outcome of ischemic stroke.The development of neuroinflammation during the acute phase of ischemic stroke leads to secondary damage and subsequently to various complications.The discoveries of meningeal lymphatic vessels in the human brain have changed our understanding of the mechanisms of neuroinflammation in ischemic stroke, suggesting that glymphatic dysfunction underlies immune dysfunction and central nervous system drainage.In this presentation, I will review methods of influencing the pathogenetic link of neuroinflammation by administering a drug lymphotropically.

Speaker: Yarashev Akmal Rustamovich – head of the neuroreanimation department of the Bukhara branch of the Republican Scientific Center for Emergency Medical Care, assistant of the Department of Anesthesiology and Reanimatology of the Bukhara State Medical Institute.He completed clinical residency in anesthesiology and resuscitation at the Bukhara Medical Institute in 2002-2004, and postgraduate studies at the Tashkent Institute for Advanced Medical Studies and Postgraduate Education in 2007-2010.In 2010, he defended his Ph.D. thesis on the topic “Monitoring of cerebral perfusion pressure in intensive care for hemorrhagic stroke” at the Academic Council of the Tashkent Medical Academy.During his medical career, he completed an internship in stroke centers in Germany, Turkey, India and Japan.

Scientific activity of Yarashev A.R. focused on studying the problem of neuroinflammation and developing new methods of intensive therapy for cerebrovascular diseases. He is the author of more than 60 publications - theses, articles and methodological recommendations.

Abstract: Stenosis or occlusion of carotid arteries because of their atherosclerotic lesions leads to chronic brain hypoperfusion, dysfunctions of the cerebral vasculature and nerve centers involved in the regulation of systemic hemodynamics. In addition, stenosis of carotid arteries disrupts the functioning of the sinocarotid baroreflex, which increasesblood pressure variability and can aggravate pathological changes in both systemic and cerebral circulation. In my report, I will present data on the regulation of cerebral and systemic hemodynamics in patients with carotid stenosis, as well as those obtained in an animal model of this pathology (vascular studies with the use of in vitro and in vivo techniques). Importantly,our data show the character of the observed changes may be either detrimental or compensatory, depending on the duration and severity of the disease. This should be considered when assessing the degree of cerebral vasoregulation disorder and predicting the course of this disease. The work was supported by a grant from the Russian Science Foundation, # 23-15-00331.

Speaker: Olga Tarasova — Head of the Department of Physiology and Pathology, Faculty of Basic Medicine, Lomonosov Moscow State University (MSU) and chief researcher at the Laboratory of Exercise Physiology, Institute of Biomedical Problems. In 1984, she graduated from the Department of Biology at MSU, qualifying as a physiologist. Received a Candidate of Science degree in 1990 and a Doctor of Science degree in 2005.The field of research interests – physiology of circulation and autonomic nervous system. In 1995, during a visit to Sweden and Denmark, she mastered the method of wire myography, then implemented it in MSU for experiments tiny arterial vessels.PIof many research projects supported by the Russian Foundation for Basic Research and the Russian Science Foundation.Laureate of the V.V. Parin Prize (Presidium of RAS) for the work "Regulation of blood circulation during adaptation to extreme conditions". In recent years, her research team has been focused on alterations of vascular control in challenges of perinatal development and hypokinesia (conditions of microgravity), including their detrimental effects on cerebral vasculature.

Abstract: The human brain exemplifies a highly nonlinear, dynamic, and multiscale complex system, presenting profound challenges for interpretation and real-time monitoring. This talk presents recent advances in signal processing techniques designed to analyze brain dynamics through modalities such as EEG, MEG, and fMRI. We explore modern approaches including time-frequency decomposition, entropy and fractal-based complexity analysis, graph signal processing, and deep neural architectures for extracting high-resolution insights from neural signals.

A significant focus will be on the convergence of joint bio-sensing with secure communication, a critical paradigm for future neurotechnology applications such as brain-computer interfaces, cognitive load estimation, and remote neuro-health monitoring. Here, the fusion of advanced signal processing with secure wireless protocols ensures real-time, privacy-preserving transmission of sensitive brain data across embedded and mobile systems.

Furthermore, the talk will highlight the transformative potential of machine learning in decoding brain states, classifying neurological conditions, and enabling adaptive cognitive systems. We also introduce the role of quantum technologies—particularly in quantum sensing and quantum-secured communication—for achieving ultra-high sensitivity in bio-signal detection and quantum-safe data transfer. This integration unlocks new frontiers in scalable, secure, and intelligent neuro-sensing infrastructures.

Speaker: Atul Kumar conducts cutting-edge research in interdisciplinary areas and specializes in developing advanced medical technologies, including wireless medical devices, high-speed ASIC design, biomedical signal processing with advanced AI-based techniques, and 5G/6G wireless technologies. In addition, the group has two leading medical experts with expertise in neurological disorders and drugs. Moreover, he has founded two startup companies; 1) AtlaMedico TechSolutions Pvt Ltd. to develop a wireless medical device for intensive care units, an India-based technology startup for the design, optimization, and operation of a medical device (Atul Kumar et al., “Multifunctional system and method for remote monitoring of multiple physiological parameters in real time.” Patent No.: 337646); 2) Delbrone Innovation Pvt Ltd for designing and developing anti-drone systems to protect against drones in various applications such as public safety, military and others.

Abstract: Obstructive sleep apnea (OSA) is very serious and multifactorial sleep disorder which closely related with disruption of sleep homeostasis. It is known that such sleep encephalographic (EEG) phenomenon as sleep spindles (SSs) support sleep stability and may display a sleep protective function. Thus, it is of particular interest to assess the SSs pattern in OSA patient that was the aim of the present research. We investigated whether SS activity could be altered in patient with moderate degree of OSA compared with non-OSA subjects. 35 middle-aged OSA patients and 30 controls underwent full-night polysomnography (PSG). SSs were automatically detected during stage 2 (N2) of non-rapid eye movements. The SSs activity characteristics involved: total number, mean density, mean maximum amplitude and mean frequency. All differences were considered statistically significant at p <0.05. We noted a significant decrease in the density and number of central SSs in patients with OSA compared to controls, however, the amplitude is significantly higher in OSA subjects. To summarize, our results show that OSA lead to significant disruption of SSs density, reduction of their number and frequency in N2 sleep stages. These findings can be evidence of the extinction of a brain protective mechanism against exciting stimuli during apnea episodes in OSA patients with a long duration of sleep disturbances.

Speaker: Irina M. Madaeva, MD, PhD, is a Head of Irkutsk Somnological center, chief researcher of somnological and neurophysiological department of Federal State Public «Scientific Center for Family Health and Human Reproduction Problems», Irkutsk , Russia. She obtained her Ph.D. (1994) and D.Sc. (2009) in sleep medicine. Research interests include relationship between aging and sleep, modifying factors of sleep disorders, molecular mechanisms of sleep disorders, melatonin circadian rhythms, ethnic aspects of sleep disorders. Madaeva I.M. is scientific supervision of 7 scientific theses. She is member of World Association of Sleep Medicine. She is the Heard of Scientific Committee of Russian Society of Sleep Medicine . She is author more than 200 scientific papers in peer-reviewed journals, from them 162 publications in bases Web of Sciences and Scopus, Q 1-2.

Speaker:Liudmila Yakubova- Head of general practitioner and policlinic therapy department in Grodno State Medical University, Professor, MD, PhD.Author of more than 300 publications. Profiles and identifiers:ORCID https://orcid.org/0000-0001-7632-9695

Qualification:

• awarded the degree of PhD 2007,
• By the decision of the Presidium of the Higher Attestation Commission of the Republic of Belarus, he was awarded the academic title of Associate Professor in 2011,
• By the decision of the Presidium of the Higher Attestation Commission of the Republic of Belarus, the degree of Doctor of Medical Sciences was awarded in 2020,he was awarded the academic title of professor in 2021.

I had been the leader or scientific performer of several funded research projects: "Develop and implement a method for the treatment of coronary heart disease and osteoporosis by influencing the general mechanisms of their development", (2011-2013).

“To develop and implement a new method of secondary prevention and treatment of lesions of the cardiovascular system in case of deficiency /vitamin D deficiency in people with arterial hypertension» (2013-2015). "Identification of risk groups for D-vitamin deficiency", (2013-2015).

“Research on the impact of palm oil on the health of the population of the Republic of Belarus and the establishment of acceptable medical and biological levels of palm oil consumption” (2017-2018 ). Grant of the President of the Republic of Belarus (2019) for the development and implementation in general medical practice of recommendations for identifying risk factors, diagnosing and correcting D-hypovitaminosis, the use of which will help increase the primary prevention of vitamin D-associated diseases among residents of the Republic of Belarus.

"To develop new types of chocolate products enriched with protein, calcium and vitamin D, providing an increase in the balance of nutrition of preschool and school children" (2016-2020).

Research work on the project of cross-border cooperation No. RVI 1/0326/16 "Model of the medical program to combat osteoporosis in the Polish-Belarusian border area" (2018-2021).

«Develop and implement a method for assessing the risk of development and progression of atrial fibrillation in patients with arterial hypertension» (2021-2024).

Abstract: Looking into the future, neurotechnology is expected to be the most promising field in medicine. Just yesterday, it seemed fantastic to create technologies that could be controlled only by thought. But today, a number of companies Synchron Switch, Neuralink and Blackrock Neurotech have created a brain-computer interface that, using the power of thought and neurochips, makes it possible to restore movement, communication and reading in people with disabilities.

For the first time in the world, in 2023, a Russian breakthrough non-invasive technology was developed for cleansing brain tissue of toxins during sleep. This innovative direction opens a new page in the history of the development of neuroscience, when brain diseases will be treated in sleep. The technology is a portable flexible plate of LEDs that, in the infrared range, act on the meningeal lymphatic vessels, stimulating the removal of toxins (beta-amyloid and blood products) from the brain through them. Light exposure is supplied through a smart bracelet, which performs the function of monitoring sleep stages and sends a signal to photo elements via Bluetooth technology. Clinical trials of the technology will take place in 2025 on 30 patients with Alzheimer's disease and in 2026 on 30 patients with brain injuries. It is known that even one night without sleep leads to the accumulation of toxic molecules in the brain in healthy people, and in conditions of its chronic deficiency over 25 years, dementia develops. The technology is also intended to prevent dementia in healthy people who experience sleep deficiency due to overwork or in older people who experience age-related sleep disturbances. The portable size of the technology, safety and ease of use allow it to be used in a car, airplane, office and at home. The development of smart sleep technology has no analogues in the world, which contributes to the emergence of its own highly competitive niche for Russian technologies in the international arena and increases the prestige of Russian science. This will also help preserve the health of the nation, improve the quality of medical services and reduce the economic costs of treating patients with brain diseases.

Keywords: neurotechnology, medicine, photobiomodulation, Alzheimer's disease, brain injury.

Acknowledgments: The research was supported by the Russian Science Foundation grant No. 23-75-30001.

Abstract: The state of sleep is a difficult subject to study. The fact of observation and the environment by itself lead to a disruption of its natural progression. Some pathological phenomena, such as seizures, do not occur every night, which also limits the implication of the objective sleep data in clinical practice. However, for certain disorders, such as obstructive sleep apnea, REM sleep behavior disorder, bruxism, overnight polysomnography supports the diagnosis with high confidence. This is also true for some phenotypes of insomnia. The report presents examples of identification and confirmation of some pathological conditions in humans, in which the ability to objectively verify different features of sleep plays a key role.

Speaker: Mikhail Poluektov works as an associate professor at the Department of Nervous Diseases at Sechenov University in Moscow. He is also the head of the sleep medicine department at the same institution and the acting president of the Russian Society of Somnologists. In 1993 he graduated from the Medical University by I.M. Sechenov, then specialized in neurology. His PhD, received in 1998, was devoted to studying the effect of autonomic neuropathy on sleep-disordered breathing. As an associate professor, Mikhail Poluektov teaches sleep medicine in neurology and general medicine, organizes conferences on somnology, and publishes regular issues on sleep disorders in «S.S. Korsakov Journal of Neurology and Psychiatry» and «Effective pharmacotherapy». Serves as a reviewer editor in «Frontiers in Psychiatry», «Frontiers in Neurology». Author of more than 250 publications in Russian and foreign journals, 5 monographs in Russian, 3 popular books about sleep.