演讲者

Abstract: Modern optical imaging techniques provide a powerful tool to observe cortical structure and functions with high resolution. Various of skull windows have been established for different applications of cortical imaging, and each has advantages and limitations. Even none of current skull windows can be suitable for observation of the responses to some acute craniocerebral injuries at large scale and high resolution. We developed a “Through-Intact-Skull (TIS) window”, which promises us to observe immune response after traumatic brain injury at bilateral cortical scale and single-cell resolution without affecting the pathological environment of the brain. Meanwhile, TIS window has all advantages of current skull windows, including craniotomy free, centimeter-field of view, synaptic resolution, large imaging depth, long-term observation capability and compatibility for awake mice. Therefore, TIS window will be a promising new approach for intravital cortical microscopy for basic research in neuroscience.

Speaker: Dan Zhu is Distinguished Professor of Huazhong University of Science and Technology, SPIE/OPTICA Fellow, Director of Advanced Biomedical Imaging Facility, Vice-director of Wuhan National Laboratory for Optoelectronics. She has been developing tissue optical clearing methods for obtaining in vivo cortical neurovascular structure and function, as well as 3D structure of organs. She has owned more than 200 peer-review papers in Science Advances、Nature Communications、Light: Science & Applications et al, and 100 plenary or invited talk on international conferences, including SPIE Bios Hot Topic. She is an Associate editor of Journal of Biomedical Optics,except executive Editor-in-Chief of Frontier of Optoelectronics：Biomedical Photonics，Editorial Member or Guest Editor of Biomedical Optics Express, Scientific Reports, Journal of Innovative Optical Health Sciences, and Frontier of Optoelectronics etc.

Abstract: Spatial multi-omics technology is of great significance for understanding the interactions between cells and the influence of spatial location on cellular omics in brain tissues, which has become a research hotspot in recent years. Currently, a variety of spatial multi-omics technologies have emerged, and how to balance sample throughput, omics throughput, and cost is an important issue to be considered in spatial multi-omics analysis. In this work, we explored the low-throughput spatial sampling and encoding methods based on the principle of microdissection, and on this basis, achieved the acquisition of low-to-medium throughput and low-cost multi-omics data. The research results show that our method has a relatively high cost-performance ratio and has potential application value in neuroscience.

Speaker: Xiangwei Zhao is a professor of State Key Laboratory of Digital Medical Engineering, Southeast University. He graduated from Zhejiang University with a doctoral degree in 2006. He has successively served as a visiting scholar at the Institute of Laser Engineering, Osaka University, Japan; the Department of Biomedical Engineering, University of Michigan, USA; the Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, USA; and Harvard Medical School. Currently, his research focused on bio-barcode technology. The research themes include spatial omics, brain organoids, POCT, DNA information storage, biomedical big data, etc. He was PI of more than 10 projects, such as the National Natural Science Foundation of China grant, the National Key R & D Program projects, and the Science and Technology Support Program of Jiangsu Province. He has published more than 100 SCI papers and transferred 9 invention patents. He has won the First Prize of the Natural Science Award from the Ministry of Education, the Second Prize of the Technological Invention Award of the "Huang Jiasi Biomedical Engineering Award" by the Chinese Society of Biomedical Engineering, and the Gold Medal at the Geneva International Invention Exhibition. He has been selected as an Excellent Talent in the New Century by the Ministry of Education, a Middle-aged and Young Academic Leader in the Qinglan Project of Jiangsu Province, a High-level Talent in the "Six Talent Peaks" Project of Jiangsu Province, and a "Zijin Young Scholar" and a "Huaying Scholar" at Southeast University.

Abstract: Hyperspectral technology, as a non-destructive, non-contact optical detection method that integrates image and spectral information, has expanded its application scope from the traditional field of remote sensing to advanced machine vision and microscopic imaging technologies. This report provides a detailed analysis of the latest advancements in the field of hyperspectral technology, with a particular focus on the unique characteristics of different spectral dispersion techniques and their most suitable application fields. Through a series of comprehensive case studies, the report highlights the innovative applications of microscopic spectral imaging technology, especially near-infrared spectral imaging, in life science research. These advancements offer new analytical tools and development opportunities for the field, opening up entirely new research directions.

Speaker: Xudong Luo is the founder and general manager of NBL IMAGING SYSTEM LTD., graduated from Wuhan Huazhong University of science and technology, has been engaged in the application and promotion of hyperspectral imaging and related technologies for many years. In 2007, he participated in and completed the key technology research of spectral imaging, a national science and technology support program of the Ministry of science and technology of the people's Republic of China during the 11th Five Year Plan period, and formed the transformation achievement: spectral image analysis software for material evidence identification imaging. In 2010, he participated in the research project" identification of human individual and key technology of material evidence traceability”with the topic of key technology of examination and traceability of material evidence and equipment development under the national 12th Five Year Plan science and technology support. In 2015, he participated in the sub topic of "development technology of multi spectrum fusion on-the-spot detection equipment of biological evidence" of the project "key technology of investigation on the scene of the case and analysis of target correlation of the National key R & D plan of 13th Five Year period. At the same time, he is also a member of the Committee of hyperspectral imaging for remote sensing detection, a member of the China Association of criminal science and technology, and a member of Expert Committee on Biomedical Engineering Photonics and holding a number of applied / authorized invention patents.

Abstract: Acquiring the three-dimensional (3D) structure of biological tissues is essential for research in life sciences. Modern optical imaging techniques and fluorescent labeling technologies have provided vital tools for obtaining high-resolution information on the 3D structures of biological tissues. However, the turbid nature of biological tissues limits the depth of light penetration, leading to restricted applications for large tissues or whole organs. Tissue optical clearing technology takes a different approach by making the tissues transparent using various physical and chemical strategies to reduce the attenuation of light in tissues, and providing a new approach for the 3D imaging of whole organs. Here, we will introduce our progress in the research of ex vivo tissue optical clearing methods and applications, covering the fluorescence labeling, tissue clearing, and imaging of whole organs, as well as the applications in neuroscience.

Speaker: Tingting Yu is an Associate Researcher at the Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology. She is mainly engaged in research on tissue optical clearing methods and applications, focusing on the development of optical imaging techniques based on tissue clearing for obtaining and reconstructing three-dimensional structure information of the central nervous system, peripheral nervous system, and other biological tissues. She has published over 30 SCI papers in journals such as Science Advances, Nature Communications, and Theranostics, and has contributed to the compilation of four Chinese and English monographs, with eight authorized patents. She has led projects including the General Project, Young Scientists Fund from NSFC, International Cooperation and Exchanges Projects from NSFC, and Hubei Province's Key R&D Program, as well as participating in Key R&D projects of the Ministry of Science and Technology and the Key International Cooperation Research Projects of NSFC. She is a Young Committee Member and the deputy secretary-general of the Biomedical Optics Professional Committee of the Chinese Optical Society.

Abstract: Transcranial photobiomodulation (tPBM), a non-invasive neurostimulation technique using near-infrared or red light, has emerged as a promising therapy for various brain disorders. By targeting specific brain regions, tPBM is hypothesized to modulate mitochondrial function, reduce neuroinflammation, and promote neurogenesis, thereby accelerating recovery processes. Here, we will introduce our progress in tPBM to promote the prognosis of ventricular hemorrhage, enhance microglial function in diabetic mice, and improve cognitive function in Alzheimer's disease mice. In addition, we provide preliminary evidence of a potential mechanism of tPBM that promotes dilation of meningeal lymphatic vessels to improve their drainage function, thereby improving brain function.

Speaker: Shaojun Liu is a postdoc of Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology. He graduated from Huazhong University of Science and Technology with a doctoral degree in 2024. Currently, his research focuses on the biomedical applications of in vivo tissue optical clearing methods and near-infrared photobiomodulation to improve brain diseases. He has published more than 10 peer-review papers in Nature Communications, Communications Biology, Analytical Chemistry and other journals.

Abstract: Acute ischemic stroke affects millions of people every year. Recent research data indicate the involvement of the glymphatic system in the process. The balance of pro- and anti-inflammatory interleukins is one of the pathogenetic mechanisms of the development of neuroinflammation that determines the course and outcome of ischemic stroke.The development of neuroinflammation during the acute phase of ischemic stroke leads to secondary damage and subsequently to various complications.The discoveries of meningeal lymphatic vessels in the human brain have changed our understanding of the mechanisms of neuroinflammation in ischemic stroke, suggesting that glymphatic dysfunction underlies immune dysfunction and central nervous system drainage.In this presentation, I will review methods of influencing the pathogenetic link of neuroinflammation by administering a drug lymphotropically.

Speaker: Yarashev Akmal Rustamovich – head of the neuroreanimation department of the Bukhara branch of the Republican Scientific Center for Emergency Medical Care, assistant of the Department of Anesthesiology and Reanimatology of the Bukhara State Medical Institute.He completed clinical residency in anesthesiology and resuscitation at the Bukhara Medical Institute in 2002-2004, and postgraduate studies at the Tashkent Institute for Advanced Medical Studies and Postgraduate Education in 2007-2010.In 2010, he defended his Ph.D. thesis on the topic “Monitoring of cerebral perfusion pressure in intensive care for hemorrhagic stroke” at the Academic Council of the Tashkent Medical Academy.During his medical career, he completed an internship in stroke centers in Germany, Turkey, India and Japan.

Scientific activity of Yarashev A.R. focused on studying the problem of neuroinflammation and developing new methods of intensive therapy for cerebrovascular diseases. He is the author of more than 60 publications - theses, articles and methodological recommendations.

Abstract: Stenosis or occlusion of carotid arteries because of their atherosclerotic lesions leads to chronic brain hypoperfusion, dysfunctions of the cerebral vasculature and nerve centers involved in the regulation of systemic hemodynamics. In addition, stenosis of carotid arteries disrupts the functioning of the sinocarotid baroreflex, which increasesblood pressure variability and can aggravate pathological changes in both systemic and cerebral circulation. In my report, I will present data on the regulation of cerebral and systemic hemodynamics in patients with carotid stenosis, as well as those obtained in an animal model of this pathology (vascular studies with the use of in vitro and in vivo techniques). Importantly,our data show the character of the observed changes may be either detrimental or compensatory, depending on the duration and severity of the disease. This should be considered when assessing the degree of cerebral vasoregulation disorder and predicting the course of this disease. The work was supported by a grant from the Russian Science Foundation, # 23-15-00331.

Speaker: Olga Tarasova — Head of the Department of Physiology and Pathology, Faculty of Basic Medicine, Lomonosov Moscow State University (MSU) and chief researcher at the Laboratory of Exercise Physiology, Institute of Biomedical Problems. In 1984, she graduated from the Department of Biology at MSU, qualifying as a physiologist. Received a Candidate of Science degree in 1990 and a Doctor of Science degree in 2005.The field of research interests – physiology of circulation and autonomic nervous system. In 1995, during a visit to Sweden and Denmark, she mastered the method of wire myography, then implemented it in MSU for experiments tiny arterial vessels.PIof many research projects supported by the Russian Foundation for Basic Research and the Russian Science Foundation.Laureate of the V.V. Parin Prize (Presidium of RAS) for the work "Regulation of blood circulation during adaptation to extreme conditions". In recent years, her research team has been focused on alterations of vascular control in challenges of perinatal development and hypokinesia (conditions of microgravity), including their detrimental effects on cerebral vasculature.

Abstract: The human brain exemplifies a highly nonlinear, dynamic, and multiscale complex system, presenting profound challenges for interpretation and real-time monitoring. This talk presents recent advances in signal processing techniques designed to analyze brain dynamics through modalities such as EEG, MEG, and fMRI. We explore modern approaches including time-frequency decomposition, entropy and fractal-based complexity analysis, graph signal processing, and deep neural architectures for extracting high-resolution insights from neural signals.

A significant focus will be on the convergence of joint bio-sensing with secure communication, a critical paradigm for future neurotechnology applications such as brain-computer interfaces, cognitive load estimation, and remote neuro-health monitoring. Here, the fusion of advanced signal processing with secure wireless protocols ensures real-time, privacy-preserving transmission of sensitive brain data across embedded and mobile systems.

Furthermore, the talk will highlight the transformative potential of machine learning in decoding brain states, classifying neurological conditions, and enabling adaptive cognitive systems. We also introduce the role of quantum technologies—particularly in quantum sensing and quantum-secured communication—for achieving ultra-high sensitivity in bio-signal detection and quantum-safe data transfer. This integration unlocks new frontiers in scalable, secure, and intelligent neuro-sensing infrastructures.

Speaker: Atul Kumar conducts cutting-edge research in interdisciplinary areas and specializes in developing advanced medical technologies, including wireless medical devices, high-speed ASIC design, biomedical signal processing with advanced AI-based techniques, and 5G/6G wireless technologies. In addition, the group has two leading medical experts with expertise in neurological disorders and drugs. Moreover, he has founded two startup companies; 1) AtlaMedico TechSolutions Pvt Ltd. to develop a wireless medical device for intensive care units, an India-based technology startup for the design, optimization, and operation of a medical device (Atul Kumar et al., “Multifunctional system and method for remote monitoring of multiple physiological parameters in real time.” Patent No.: 337646); 2) Delbrone Innovation Pvt Ltd for designing and developing anti-drone systems to protect against drones in various applications such as public safety, military and others.

Abstract: Obstructive sleep apnea (OSA) is very serious and multifactorial sleep disorder which closely related with disruption of sleep homeostasis. It is known that such sleep encephalographic (EEG) phenomenon as sleep spindles (SSs) support sleep stability and may display a sleep protective function. Thus, it is of particular interest to assess the SSs pattern in OSA patient that was the aim of the present research. We investigated whether SS activity could be altered in patient with moderate degree of OSA compared with non-OSA subjects. 35 middle-aged OSA patients and 30 controls underwent full-night polysomnography (PSG). SSs were automatically detected during stage 2 (N2) of non-rapid eye movements. The SSs activity characteristics involved: total number, mean density, mean maximum amplitude and mean frequency. All differences were considered statistically significant at p <0.05. We noted a significant decrease in the density and number of central SSs in patients with OSA compared to controls, however, the amplitude is significantly higher in OSA subjects. To summarize, our results show that OSA lead to significant disruption of SSs density, reduction of their number and frequency in N2 sleep stages. These findings can be evidence of the extinction of a brain protective mechanism against exciting stimuli during apnea episodes in OSA patients with a long duration of sleep disturbances.

Speaker: Irina M. Madaeva, MD, PhD, is a Head of Irkutsk Somnological center, chief researcher of somnological and neurophysiological department of Federal State Public «Scientific Center for Family Health and Human Reproduction Problems», Irkutsk , Russia. She obtained her Ph.D. (1994) and D.Sc. (2009) in sleep medicine. Research interests include relationship between aging and sleep, modifying factors of sleep disorders, molecular mechanisms of sleep disorders, melatonin circadian rhythms, ethnic aspects of sleep disorders. Madaeva I.M. is scientific supervision of 7 scientific theses. She is member of World Association of Sleep Medicine. She is the Heard of Scientific Committee of Russian Society of Sleep Medicine . She is author more than 200 scientific papers in peer-reviewed journals, from them 162 publications in bases Web of Sciences and Scopus, Q 1-2.

Speaker:Liudmila Yakubova- Head of general practitioner and policlinic therapy department in Grodno State Medical University, Professor, MD, PhD.Author of more than 300 publications. Profiles and identifiers:ORCID https://orcid.org/0000-0001-7632-9695

Qualification:

• awarded the degree of PhD 2007,
• By the decision of the Presidium of the Higher Attestation Commission of the Republic of Belarus, he was awarded the academic title of Associate Professor in 2011,
• By the decision of the Presidium of the Higher Attestation Commission of the Republic of Belarus, the degree of Doctor of Medical Sciences was awarded in 2020,he was awarded the academic title of professor in 2021.

I had been the leader or scientific performer of several funded research projects: "Develop and implement a method for the treatment of coronary heart disease and osteoporosis by influencing the general mechanisms of their development", (2011-2013).

“To develop and implement a new method of secondary prevention and treatment of lesions of the cardiovascular system in case of deficiency /vitamin D deficiency in people with arterial hypertension» (2013-2015). "Identification of risk groups for D-vitamin deficiency", (2013-2015).

“Research on the impact of palm oil on the health of the population of the Republic of Belarus and the establishment of acceptable medical and biological levels of palm oil consumption” (2017-2018 ). Grant of the President of the Republic of Belarus (2019) for the development and implementation in general medical practice of recommendations for identifying risk factors, diagnosing and correcting D-hypovitaminosis, the use of which will help increase the primary prevention of vitamin D-associated diseases among residents of the Republic of Belarus.

"To develop new types of chocolate products enriched with protein, calcium and vitamin D, providing an increase in the balance of nutrition of preschool and school children" (2016-2020).

Research work on the project of cross-border cooperation No. RVI 1/0326/16 "Model of the medical program to combat osteoporosis in the Polish-Belarusian border area" (2018-2021).

«Develop and implement a method for assessing the risk of development and progression of atrial fibrillation in patients with arterial hypertension» (2021-2024).

Abstract: Fundamental science is the foundation for applied technologies. However, it always remains unknown which ideas will be able to transform into technologies and enter the market. Is it possible to make the process of transferring fundamental ideas to the market fast and reliable? How long will it take? What rules should be developed for this?
Based on our RSF mega grant No. 23-75-30001, I will give an example of the life cycle of a medical technology from TRL 0 to TRL 8 in just 2 years. For the rapid transfer of a scientific idea to the market, two factors must be a prerequisite: 1) an industrial partner who is ready to produce a new technology; 2) practicing doctors who will conduct clinical trials, i.e. the medical organization in which doctors work must be accredited to conduct clinical trials. These two conditions will allow the most effective adaptation of the design and composition of the technology to the capabilities of the industrial partner and the medical conditions of its application. This will also help to take into account the necessary requirements for the materials from which the technology will be made, because all medical devices must be made from certified materials, i.e. approved in a particular country for use on humans.
After manufacturing the technology, an important stage is the preparation of documents for its technological and toxicological testing. In this case, it is important to use the services of certified companies, preferably operating on the basis of medical institutions, which will help in the correct preparation of documents. After receiving certificates for technical and toxicological tests, these companies can also help in submitting documents to the Ministry of Health, which issues permission to conduct clinical trials. Approval of the clinical trial plan is approved by the ethics committee of the medical organization appointed for this by the Ministry of Health. Upon completion of clinical trials and receipt of positive results, the Ministry of Health issues a registration certificate for the technology, assigning it the status of medical equipment. After this, the industrial partner launches production of the technology on its site and brings it to the medical equipment market when it becomes commercially available. Thus, for efficient and fast (in 2-3 years) implementation of the life cycle of the developed technology from TRL 0 to TRL 8, already at the initial stages, the presence of an interested industrial partner ready to produce the technology and qualified doctors ready to apply this technology in their clinical practice is required. With these two factors, the translation of the technology from the idea to its launch on the market becomes reliable with minimal risks.

Keywords: neurotechnology, medicine, photobiomodulation, Alzheimer's disease, brain injury.

Acknowledgments: The research was supported by the Russian Science Foundation grant No. 23-75-30001.

Abstract: Obstructive sleep apnea (OSA) is a very serious and multifactorial sleep disorder in relation to the risk of developing cognitive impairment. There are main pathogenetic mechanisms of OSA such as remittent nocturnal hypoxemia and altered sleep homeostasis, which through a cascade of pathophysiological reactions (endothelial dysfunction, oxidative stress, neuroinflammation, cerebral hypoperfusion et al.) could initiate disruptions in cellular and biochemical homeostasis to metabolic and morphofunctional changes in the brain. It is known that childhood obesity aggravates cognitive impairment in OSA. Based on the above relationships, the study aimed to evaluate the cognitive performance and their potential associations with polysomnographic (PSG) variables in OSA adolescent samples aged 15-17 years with different weight status. One-night in-lab PSG was carried out to estimate sleep data. The Wechsler Intelligence Scale for Children fourth edition (WISC-IV, Russian Version) was applied to evaluate the participants’ cognition. Full-scall cognitive ability quotient (FSCAQ), visual-spatial index, fluid reasoning index, working memory index, and processing speed index (PSI) scores were significantly lower for obese OSA adolescents. Nonobese OSA participants had significantly lower FSCAQ and PSI scores compared with those in controls without OSA but were similar who was obese by all WISC-IV indexes. Multiple linear regression analysis revealed that k-complexes (KK) density, «sleep spindles» (SSs) duration and wake after sleep onset for nonobese adolescents, as well as apnea-hypopnea index, oxygen desaturation index, number of awaking, KKs and SSs densities, and sleep fragmentation index for obese peers were negative associated with cognitive functions. In conclusion, the cognitive performance in pediatric OSA is decreasing with a predominant deterioration of non-verbal abilities, due to alteration of sleep homeostasis in OSA without obesity, and the potentiated effect of hypoxia severity and sleep fragmentation in obesity.

Speaker: Olga Berdina is PhD, Leading researcher of Laboratory of Somnology and Neurophysiology of Scientific Centre for Family Health and Human Reproduction Problems, Pediatrician and Functional Diagnostics Specialist of Innovation Center of Scientific Centre for Family Health and Human Reproduction Problems. She has been conducting research in the field of fundamental and applied aspects of sleep disorders and associated conditions in pediatrics, developing innovative technologies for their early diagnosis, prevention and prognosis. She has owned more than 100 peer-review papers in Sleep Medicine, Journal of Sleep Research, Sleep and Biological Rhythms, Frontiers in Pediatrics, The European Physical Journal, Canadian Respiratory Journal, Archives of Disease in Childhood et al., and 100 sectionally or invited talk on international conferences, including Forum BRICS, ECOG, Europaediatrics, Congress of the Asian College of Psychosomatic Medicine IPA Congress & PEDICON et al.

Abstract: MRI imaging with spinal labeling are widely used in brain perfusion. The idea is in label the thin slice of liquid and check it’s distribution after some time. The water molecules are magnetically labeled (tagged) by using a radiofrequency pulse that saturates water protons and enhance its visibility in magnetic resonance imaging. Subtraction between labeled image and the control non labeled image with the static tissue signals eliminate the non labeled static signals. The resulting image is proportionate to the liquid flow. Arterial spinal labeling (ASL) widely used for high speed blood flow registration und uses single water labeling in neck artierias and not suitable for low speed lymphatic flows. For such a flows it’s used the inter-slice liquid perfusion MRI called alternate ascending/descending directional navigation (ALADDIN). In ALADDIN protocol not the whole brain, but the single layer is measured and the measured layer is parallel to the labeling layer and shifted in flow direction. To cover all the brain, the multiple labeling and registrations are required. Our enhancement of ALLADIN protocol and its applications I will describe in details.

Speaker: Pavel Rudych is an engineer and project manager at Novosibirsk State University and the International Tomography Centre of Novosibirsk. Pavel received his M.S. in Physics from Novosibirsk State University, Russia, in 2005 and his second B.S. in Clinical Psychology in 2021. His research interests are in functional MRI and coregistered EEG experiments, experiment stimulus gamification and environmental transparency based on web, EEG/MRI data aggregation and automated processing, machine learning analysis. Pavel is the author of more than 30 peer-reviewed publications.

Abstract: Dizziness and vertigo: causes, diagnosis, principles of treatment Dizziness is a nonspecific symptom that describes a sensation of abnormal rotation of the head, or the sensation of the external environment spinning. It affects 50% of elderly patients and is the commonest cause of complaint in patients over 75 years of age. It may be physiological, occurring during or after a sustained head rotation, or pathological, due to vestibular dysfunction. It divided to peripheral and central. Peripheral vertigo is due to disorders that affect the labyrinths or vestibular nerves. Central vestibular causes are multiple sclerosis, migraine, epilepsy. Vertigo may be paroxysmal or chronic. In diagnosing the vertigo causes, we will use the data of physical examination, special tests, data of laboratory and instrumental examination. Treatment depends on the causes of dizziness.

Speaker: Tatyana Pronko, MD, PhD is a Head of the Department of Propaedeutics of Internal Diseases of Grodno State Medical University, Belarus since 2012. She defended scientific degree (PhD) "Study of endothelial dysfunction and blood oxygen transport system in patients with arterial hypertension and coronary artery disease” in 2003. Pronko T. is scientific supervisor of 1 scientific theses “Study of arterial stiffness in patients with arterial hypertension after ischemic stroke”. In the near future, two more people are planning to defend their thesis completed under her supervision. Current research interests include platelet aggregation, clinical and laboratory factors influencing high and low residual platelet reactivity in patients with myocardial infarction.She has over 290 publications, 22 of them are in Web of Sciences and Scopus bases. She is member of European Cardiology Society and Russian Cardiology Society.

Abstract: Secondary damage after traumatic brain injury is a serious problem in neurocritical care, which leads to increased neuroinflammation and cerebral edema. It is known that secondary brain lesions play a significant role in the pathogenesis of severe closed traumatic brain injury, leading to edema, increased intracranial pressure, dislocation of vital centers and unfavorable outcome.Despite a number of factors influencing the high mortality associated with traumatic brain injury, the development of cerebral edema is the most significant predictor of unfavorable outcome.Various pharmacological treatment options have not demonstrated benefit in traumatic brain injury.In this presentation, I will review clinical developments to target neuroinflammation and cerebral edema in traumatic brain injury in the context of recent progress made in the field of the glymphatic system of the brain.

Speaker: Olim Sh. Eshonov – Associate Professor of the Department of Anesthesiology and Reanimatology, Bukhara State Medical Institute.He underwent specialization and advanced training at the Institute of Emergency and Emergency Care named after. Sklifosovsky in Moscow 1984 1986, 1991 on the basis of the Moscow Medical Academy in the “Clinical Lymphology” cycle.In 1991, he defended his PhD thesis at the Moscow Medical Academy on the topic “Endolymphatic antibiotic therapy for acute septic brucellosis.”His research focuses on developing new treatments for traumatic brain injury, stroke and other cerebrovascular diseases.

Dr. Eshonov is the author of more than 150 publications and textbooks “Anesthesiology and Resuscitation” and “Emergency Conditions”, the manual “Anesthesiology, Resuscitation and Intensive Care”, received three patents for new methods of treating and diagnosing diseases.

Abstract: The concept of sleep medicine implies that our knowledge on the human body functioning during sleep can help in developing new methods of diagnosis and treatment. Since sleep is a product of the central nervous system, it is obvious that nervous diseases can have a greater impact on its occurrence or continuation. This can be registered by objective methods. An example of the importance of such approach can be the differentiation of the psychogenic neurological signs (pseudotremor, pseudodystonia, functional hemiparesis). They disappear during sleep, since voluntary control of motor functions is lost. Sleep can be disturbed for years (more than 50) before the clinical manifestationof a neurological disease. In the study of REM sleep behavior disorder 95% of cases of synucleinopathy (Parkinson's disease or dementia with Lewy bodies) develops within 20 years.
It is possible to achieve a better control of the course of nervous disease by improving sleep. The use of CPAP therapy in patients with ischemic stroke with obstructive sleep apnea leads to a 2.9-fold decrease of recurrent strokes. Improved sleep after the course of cognitive-behavioral therapy of insomnia is accompanied by a decrease of systemic inflammation. The activation of the glymphatic drainage system of the brain during sleep was discovered ten years ago. It looks promising that the pharmacological or nonpharmacological stimulation of this system leads to the maintenance of cognitive reserves in the elderly.

Speaker: Mikhail Poluektov works as an associate professor at the Department of Nervous Diseases at Sechenov University in Moscow. He is also the head of the sleep medicine department at the same institution and the acting president of the Russian Society of Somnologists. In 1993 he graduated from the Medical University by I.M. Sechenov, then specialized in neurology. His PhD, received in 1998, was devoted to studying the effect of autonomic neuropathy on sleep-disordered breathing. As an associate professor, Mikhail Poluektov teaches sleep medicine in neurology and general medicine, organizes conferences on somnology, and publishes regular issues on sleep disorders in «S.S. Korsakov Journal of Neurology and Psychiatry» and «Effective pharmacotherapy». Serves as a reviewer editor in «Frontiers in Psychiatry», «Frontiers in Neurology». Author of more than 250 publications in Russian and foreign journals, 5 monographs in Russian, 3 popular books about sleep.